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Although the recurrent tumor from patient 1 retained heterozygosity at all informative loci on 17p, one copy of the p53 gene contained a G to A transition in codon 173 of exon 5 and also suffered loss of heterozygosity on chromosome 10 as detected by the D10S28 marker. The recurrent tumor from patient 16 suffered allelic losses at multiple 17p loci together with a T to C transition in codon 145 of exon 5 of the remaining copy of the p53 gene and also [url=http://www.lotogame.fr/louboutin-pas-cher/]louboutin[/url] contained high copy number of the PDGFR gene (Figure 1a). Overexpression of both [url=http://www.jeremyparendt.com/Barbour-Paris.php]barbour pas cher soldes[/url] and forms of PDGFR at [url=http://www.tesangay.com/barbour.php]barbour deutschland[/url] the protein level (Fleming et al., 1992) [url=http://www.diecastlinks.co.uk]hollister uk[/url] and amplification of the CDK4 gene (Saxena et al., 1996) were also detected in the recurrent tumor of patient 16.Figure 1b demonstrates homozygous deletion of the DMBT1 gene, located on 10q25.3 26.1 (Mollenhauer et al., 1997), in the recurrent tumor of patient 53.
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